A Combination Not to Be Underestimated and Managed
Editorial published in Ex-Dairy Press 2023
Oxidative processes are fundamental to life, and organisms with high metabolic activity, such as high-yield dairy cows, are at risk of oxidative stress, especially during certain physiological or seasonal moments (such as parturition, thermal stress conditions, or during mastitis or influenza-like states), which we must prevent and manage in their dysregulated evolution, leading to an inflammatory condition.
How can we act? The answer once again comes from nature, which contains the most effective remedies for rebalancing suboptimal oxidative and inflammatory conditions, utilizing the effects of polyphenols and salicylates that, when appropriately selected and dosed, have been used in the formulation of Normoterm.
What do studies report about the effects of polyphenols and salicylates?
Several studies on natural phytocompounds, such as polyphenols and salicylates, have extensively demonstrated their efficacy on animal metabolism, acting as antioxidants (and thus preventing cell damage due to lipid peroxidation of the cell membrane) and alleviating inflammation.
Polyphenols
One of the major sources of polyphenols comes from lignin derived from Pinus taeda.
LIGNIN is a heavy polymeric complex made up of phenylpropane units. There are three monomers present in varying ratios in all lignins: coniferyl alcohol, coumaryl alcohol, and sinapyl alcohol.
The union of these monomers creates a class of phenols commonly called lignans, which in the plant have a defensive function against pathogens (fungi, bacteria, and viruses) and antioxidant protection of the plant’s sensitive parts (young branches, leaves, buds, fruits) from solar radiation.
Lignans, introduced into mammals through the diet, are modified by intestinal bacteria, absorbed, and then subject to enteroportal circulation.
Mechanism of Action
A polyphenolic concentrate, derived from an extraction and partial hydrolysis process of cellulose from Pinus taeda wood, when administered with the animal diet, is responsible for the following actions:
1. Free radical scavenging
2. Antibacterial action
3. Antiviral action
4. Antimycotoxin action
5. Antidiarrheal action
Salicylates
Salicylic acid, the active compound in aspirin, in its acetylated form, is a substance first extracted from willow bark.
This substance, produced by plants to protect themselves from chemical, physical, and biological attacks, is an anti-inflammatory useful in various febrile situations as an antipyretic or as a mild analgesic.
Mechanism of Action
1. Reduction of prostaglandins (PG) by inhibiting cyclooxygenase
2. Antioxidant effect of haptoglobin
3. Reduction of body temperature by acting on thermoregulatory neurons
Zootechnical Effects of Using Normoterm Orac*
Normoterm is used in all conditions where there is a need to counteract the risk of oxidative stress and its consequent inflammatory drift. Such situations are observed during infectious diseases such as mastitis, metritis, or so-called influenza-like states, or conditions of potential severe oxidative stress such as in the postpartum period of the cow or during summer thermal stress periods.
In these latter cases, the positive effects of using polyphenols and salicylates contained in Normoterm not only improve the health status of treated animals but also have a significant positive effect on fertility, preserving the integrity of oocytes and embryos from the negative consequences of oxidative and inflammatory processes.
In this regard, we report an interesting trial using Normoterm in fresh cows during the first 30 days postpartum: tracking the zootechnical performance of these animals, it was observed that they demonstrated a significant positive effect from the treatment with Normoterm, both regarding oxidative status (measured as TAS) and health, as well as an evident improvement in reproductive performance in terms of CR (Conception Rate) and PR (Pregnancy Rate).
Tecnozoo Trial of Normoterm Orac Usage*
WHERE: Agrifutura REAL KFT REAL KFT -TÁRNOK -HU. 600 dairy cows, of which 500 are in milking – 650 heifers.
PURPOSE: To assess the effects of administering a product containing antioxidant active ingredients given at calving and during the first 30 days of lactation in Holstein cows.
HOW
• 300 g/head within the first 12 hours after calving in the drench.
• 50 g/head/day during the 30 days postpartum mixed in TMR.
WHEN: July – November 2016.
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